Your Partner in
Next-Generation
Neurotoxicity
Testing

DNTOX specializes in providing cutting-edge, 
animal test-free, in vitro 2D and 3D test systems, and toxicological testing services to assess chemical effects on the human nervous system, with a focus on developmental and adult neurotoxicity.

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Why choose dntox

Our innovative approach overcomes the limitations of traditional testing

Traditional animal studies are expensive, slow, and often fail to accurately predict effects specific to the human nervous system. Many simpler in vitro systems struggle to capture the complex, multi-step processes of human neurodevelopment.

Human-Based Relevance

We use advanced human-based, multicellular, and multiplexed 2D & 3D in vitro systems.

Industry Standards

Our methods leverage internationally recognized proof-of-concept and are aligned with OECD-recommended testing.

Comprehensive Tests for Critical Neuronal Processes

DNTOX provides comprehensive test methods to evaluate critical neurodevelopmental and neurofunctional processes, including:

  • Cell differentiation
  • Neurite outgrowth
  • Network formation
  • General cytotoxicity
Reliable Data from Robust Workflows for Critical Decisions

By integrating biologically relevant model systems with standardized, robust analysis workflows, we generate reliable data to support your:

  • Compound Prioritization
  • Screening Programs
  • Hazard Identification
  • Regulatory-Oriented Decision-Making

Services

DNTOX provides cutting-edge expertise in human-relevant neural models and functional readouts, with core specialization in Developmental and Adult Neurotoxicity and highly specialized custom services in computational biology and bioinformatics.

We utilize these advanced tools to support critical safety assessments, accelerate product development, and inform regulatory decision-making across the chemical, pharmaceutical, and cosmetic industries.

Acute Toxicity & Transcriptomic Profiling
  • Acute cytotoxicity and viability screening
  • Comprehensive transcriptomic analyses (Bulk RNA sequencing)
Adult Neurotoxicity Testing (ANT)
  • Multi-Neurotransmitter Receptor Assay
Custom Solutions
  • Model Development
  • Custom assay development
Developmental Neurotoxicity Testing (DNT)
  • Proliferation of neural progenitor cells
  • Migration and differentiation studies
  • The Oligodendrocyte Assay
  • The Neural Network Formation Assay
Advanced Data Analysis
  • Biostatistics
  • Bioinformatics
Emerging Standards
  • OECD recommended DNT in vitro Testing Battery (coming soon)

Our Partners

DNTOX collaborates with customers across industry and regulators, supporting safe chemical development with human-relevant testing data.

Download brochure

Download our brochure (PDF) for an overview of services, test systems, and selected results.

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Our Team
Managing Directors:

Prof. Dr. Ellen Fritsche

Managing Director

Prof. Dr. Ellen Fritsche

Managing Director

Silke Beaucamp

Managing Director, Diploma Economist
Team:

Farina Bendt

Laboratory Head

Kay Brönstrup

Technical Assistant

Dr. Arif Dönmez

Co-Founder and Head of Bioinformatics & Biostatistics

Dr. Kristina Heck

Co-Founder and Head of R&D

Dr. Jördis Klose

Project Manager

Dr. Katharina Koch

Co-Founder and Principal Scientist - R&D

Leonie Köster

Technical Assistant

Oleksiy Nosov

Bioinformatician

Prof. Dr. Ellen Fritsche

Managing Director

Upcoming Events

DNTOX on tour at scientific meetings and industry conferences; see upcoming events for dates and details.on tour