We are using multicellular and multiplexed human-based 2D/3D in vitro systems to evaluate chemicals regarding their potential to disturb brain development and cause developmental neurotoxicity.
Experts in chemical testing and model development with a strong focus on assays
for (developmental) neurotoxicological hazard assessment
DNTOX is a German bioanalytical testing laboratory for animal-free screening of chemicals regarding their potential to disturb human brain development and cause developmental neurotoxicity (DNT). Our in vitro testing battery uses human cell models and enables artificial intelligence-based chemical screening with in-house developed software. We offer services in the following fields:
We are using multicellular and multiplexed human-based 2D/3D in vitro systems to evaluate chemicals regarding their potential to disturb brain development and cause developmental neurotoxicity.
Read moreThe DNTOX test system also includes test methods for acute neurotoxicity testing of compounds. By using 3D hiPSC-derived BrainSpheres differentiated on multi electrode arrays (MEA), we can identify different neurotransmitter receptor subtypes.
We develop machine learning empowered microscopy image and video analysis and statistical software to quantify and evaluate DNT data.
Read moreWith many years of experience, we also develop in vitro test methods for other domains of human development, as well as disease models.
