Experts in model development with a strong focus on assays for neurotoxicological hazard assessment.

DNTOX is a German bioanalytical testing laboratory for animal-free screening of chemicals regarding their potential to disturb human brain development and cause developmental neurotoxicity (DNT). Our in vitro testing battery uses human cell models and enables artificial intelligence-based chemical screening with in-house developed software.

We offer services in the following fields:

Developmental Neurotoxicity

We are using multicellular and multiplexed human-based 2D/3D in vitro systems to evaluate chemicals regarding their potential to disturb brain development and cause developmental neurotoxicity.

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Acute Neurotoxicity

The DNTOX test system also includes test methods for acute neurotoxicity testing of compounds. By using 3D hiPSC-derived BrainSpheres differentiated on multi electrode arrays (MEA), we can identify different neurotransmitter receptor subtypes.

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Computational Biology & Bioinformatics

We develop machine learning empowered microscopy image and video analysis and statistical software to quantify and evaluate DNT data.

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Model Development

With many years of experience, we also develop in vitro test methods for other domains of human development, as well as disease models.