Prof. Dr. Ellen Fritsche, MD, is the idea generator and scientific managing director of the DNTOX GmbH. Since 2012 she has been professor for environmental toxicology at Heinrich-Heine University and head of the working group ‚Development of Alternative Methods for Environmental Toxicity Testing‘ at IUF – Leibniz Institute for Environmental Medical Research in Düsseldorf. Since 2002, her research focus has been on the establishment and scientific/mechanistic validation of human ‚New Approach Methods‘ (NAMs) with the aim of regulatory application. Her neurosphere methods for developmental neurotoxicity (DNT) testing are an integral part of the DNT in vitro battery (IVB) promoted for regulatory application by the OECD (Organisation for Economic Co-operation and Development) and EFSA (European Food Safety Authority) and the US EPA (Environmental Protection Agency) (https://www.oecd.org/env/ehs/testing/developmental-neurotoxicity.htm).
Her work is funded by the EU (H2020 ENDpoiNTs, ONTOX; Horizon Europe PARC), the German Research Foundation (DFG), and industry. Ellen Fritsche is also a member of the DFG MAK Commission (Permanent Senate Commission for the Testing of Harmful Substances), the German Expert Group EU Health Research of the Federal Ministry of Education and Research (BMBF), the Scientific Advisory Board of the Einstein Center 3R, Berlin, the Bf3R Commission, BfR (Federal Institute for Risk Assessment), Berlin, the RIFM (Research Institute for Fragrance Materials) Adjunct Group on Developmental and Reproductive Toxicity, the International Scientific Advisory Board of the MRC, Centre for Environment and Health, London, UK, the Scientific Advisory Board of the OECD Expert Group preparing guidance for the use and interpretation of a DNT IVB, and the OECD Expert Group on DNT. Together with Helena Hogberg, NIH, USA, she is editor-in-chief of the journal Frontiers in Neurotoxicology.
Phone: +49 211 16786306